| Bioactivity | TNIK&MAP4K4-IN-1 (compound A-39) is a dual inhibitor of TNIK and MAP4K4/HGK with IC50s of 1.29 nM and <10 nM，respectively，in human hepaticstellate cell LX-2. TNIK&MAP4K4-IN-1 can be used for cancer and fibrosis inhibition[1]. |
| Target | IC50: 1.29 nM (TNIK), <10 nM (MAP4K4/HGK) |
| Name | TNIK&MAP4K4-IN-1 |
| CAS | 2478592-86-6 |
| Formula | C25H23FN4O3 |
| Molar Mass | 446.47 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Aliper A, et al. TNIK and/or MAP4K4 kinase inhibitors and therapeutic uses thereof in treatment of cancer and fibrosis. World Intellectual Property Organization, WO2020170203 A1 2020-08-27. |