| Bioactivity | TNIK-IN-9 (Compound 54) is a selective and potent NIK inhibitor, with an IC50 of 1.27 nM. TNIK-IN-9 can inhibit pro-inflammatory cytokines and nitric oxide production. TNIK-IN-9 exhibits significant anti-inflammatory effects, improved mortality, and hepatoprotective effects in sepsis models[1]. |
| Invitro | TNIK-IN-9 (5 μM, 2 h) 降低 LPS 和 CD40 诱导的 RAW264.7 细胞中炎症细胞因子和趋化因子 (分别为 TNF-α、IL-6、IL-1β 和 CCL12) 的水平[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> TNIK-IN-9 相关抗体: |
| In Vivo | TNIK-IN-9 (10 mg/kg，腹腔注射，一次) 抑制 LPS 诱导小鼠炎症细胞因子 (TNF-α、IL-1β、CXCL-12、IL-6、IFN-γ) 的分泌[1]。药代动力学分析[1]Route |
| Formula | C24H21N7O3S |
| Molar Mass | 487.53 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Zhang N, et al. Design, Synthesis, and Biological Evaluation of a Novel NIK Inhibitor with Anti-Inflammatory and Hepatoprotective Effects for Sepsis Treatment. J Med Chem. 2024 Apr 11;67(7):5617-5641. |