| Bioactivity | TNIK-IN-4 is a potent TNIK inhibitor with IC50 of 0.61 μM. TNIK-IN-4 has inhibitory activity against typical colorectal cancer cell line HCT116[1]. |
| Target | IC50: 0.61 μM (TNIK) |
| Invitro | TNIK-IN-4 (compound 5a) (0.4-100 μM; 72 hours) has inhibitory activity against typical colorectal cancer cell line HCT116 with IC50 of 36.423 μM[1]. Cell Proliferation Assay Cell Line: |
| Name | TNIK-IN-4 |
| CAS | 2754266-04-9 |
| Formula | C20H16FN3O3 |
| Molar Mass | 365.36 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Luo X, Yang R, Li Y, Zhang L, Yang S, Li L. Discovery of benzo[d]oxazol-2(3H)-one derivatives as a new class of TNIK inhibitors for the treatment of colorectal cancer. Bioorg Med Chem Lett. 2022;67:128745. |
TNIK-IN-4
CAS: 2754266-04-9 F: C20H16FN3O3 W: 365.36
TNIK-IN-4 is a potent TNIK inhibitor with IC50 of 0.61 μM. TNIK-IN-4 has inhibitory activity against typical colorectal
Data collection：peptidedb@qq.com
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