| Bioactivity | TNF-α agonistic 1 (compound 22a) can repolarize tumor-associated macrophages (TAMs) in the tumor microenvironment (TME) from the M2 phenotype to the M1 anti-tumor phenotype[1]. |
| CAS | 2379727-88-3 |
| Formula | C24H21ClF3N5O |
| Molar Mass | 487.90 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Pei H, et al. Discovery of potent ureido tetrahydrocarbazole derivatives for cancer treatments through targeting tumor-associated macrophages. Eur J Med Chem. 2019 Dec 1;183:111741. |
TNF-α agonistic 1
CAS: 2379727-88-3 F: C24H21ClF3N5O W: 487.90
TNF-α agonistic 1 (compound 22a) can repolarize tumor-associated macrophages (TAMs) in the tumor microenvironment (TME)
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