| Bioactivity | TNF-α-IN-19 is an inhibitor of TNFα that can block the interaction between TNFαRI, TRADD, and RIP1, the EC50 values for TNFα, IL-1β, and IL-1β/TNFα are 2.451, 3.792 and 1.54 μM, respectively. TNF-α-IN-19 only inhibits the degradation of IκBα when cells are stimulated by TNFα and not by IL-1β[1]. |
| CAS | 338773-13-0 |
| Formula | C16H8ClF3N4 |
| Molar Mass | 348.71 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Tarikere L. Gururaja, et al. A Class of SmallMolecules thatInhibit TNFa-Induced Survival and Death Pathways via Prevention of Interactions between TNFaRI, TRADD, and RIP1. Chemistry & Biology. 2007; 14(10), 1105–1118. |
TNF-α-IN-19
CAS: 338773-13-0 F: C16H8ClF3N4 W: 348.71
TNF-α-IN-19 is an inhibitor of TNFα that can block the interaction between TNFαRI, TRADD, and RIP1, the EC50 values f
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