| Bioactivity | TMP780 is an inverse agonist of RORγt with an IC50 of 13 nM. RORγt is a tractable drug target for the treatment of cutaneous inflammatory disorders[1]. | ||||||||||||
| Target | IC50: 13 nM (RORγt) | ||||||||||||
| Name | TMP780 | ||||||||||||
| CAS | 1422053-03-9 | ||||||||||||
| Formula | C31H30N2O4 | ||||||||||||
| Molar Mass | 494.58 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Skepner J, et al. Pharmacologic inhibition of RORγt regulates Th17 signature gene expression and suppresses cutaneous inflammation in vivo. J Immunol. 2014 Mar 15;192(6):2564-75. |