| Bioactivity | TMN355 is a potent chemical cyclophilin A inhibitor and reduces foam cell formation and cytokine secretion. TMN355 is used for atherosclerosis[1]. | ||||||||||||
| Target | cyclophilin A | ||||||||||||
| Invitro | TMN 355 (0.5-10 μM; 3-9 hours) results in 75.9% reduction of cyclophilin A protein expression. And 1 μM TMN 355 inhibits cyclophilin A after 6 h of activation[1]. Western Blot Analysis[1] Cell Line: | ||||||||||||
| Name | TMN355 | ||||||||||||
| CAS | 1186372-20-2 | ||||||||||||
| Formula | C21H14ClFN2O2 | ||||||||||||
| Molar Mass | 380.80 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
|
||||||||||||
| Reference | [1]. Ramachandran S, et al. Cyclophilin A enhances macrophage differentiation and lipid uptake in high glucose conditions: a cellular mechanism for accelerated macro vascular disease in diabetes mellitus. Cardiovasc Diabetol. 2016 Nov 3;15(1):152. |
TMN355
CAS: 1186372-20-2 F: C21H14ClFN2O2 W: 380.80
TMN355 is a potent chemical cyclophilin A inhibitor and reduces foam cell formation and cytokine secretion. TMN355 is us
Sales Email：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.