| Bioactivity | TLR8 agonist 8 (Compound II-72) is an agonist for Toll-like receptor 8 (TLR8) with EC50 of 0.25-1 μM. TLR8 agonist 8 is stable in human and murine plasma, induces secretion of cytokines TNFα, with EC50 <1 μM. TLR8 agonist 8 exhibits antitumor activity in MC38-HER2 xenograft mouse model with a tumor growth inhibition (TGI) rate of 89%[1]. |
| CAS | 3034750-58-5 |
| Formula | C53H63N11O10 |
| Molar Mass | 1014.14 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Zhang W, et al., Benzazepine derivative, conjugate containing same, and use thereof. WO2024067841A1. |
TLR8 agonist 8
CAS: 3034750-58-5 F: C53H63N11O10 W: 1014.14
TLR8 agonist 8 (Compound II-72) is an agonist for Toll-like receptor 8 (TLR8) with EC50 of 0.25-1 μM. TLR8 agonist 8 is
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