TLR7/8 agonist 7_product_DataBase

Bioactivity	TLR7/8 agonist 7 (compound 10) is a TLR7/8 agonist. TLR7/8 agonist 7 activates a variety of immune cells and it can be used to synthesize immune stimulating antibody conjugate (ISAC) molecules. TLR7/8 agonist 7 can be used for the research of immunity[1].
Invitro	TLR7/8 agonist 7 (compound 10) (0-1 μΜ; 24 h) is a TLR7 agonist and shows selectivity to TLR7[1].TLR7/8 agonist 7 (compound 10) (0-1 μΜ; 120 h) shows no cytotoxicity to KB cells[1].TLR7/8 agonist 7 (compound 10) (0.01, 0.1, 1, 10, 100 and 1000 nM; 48 h) induces immune cells activation[1].TLR7/8 agonist 7 (compound 10) (0.1, 1, 10, 100 and 1000 nM; 24-48 h) induces cytokine release[1]. Cell Viability Assay[1] Cell Line:
Name	TLR7/8 agonist 7
CAS	2567953-47-1
Formula	C26H37N7O2
Molar Mass	479.62
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Maderna, et al. 5H-PYRROLO[3,2-d]PYRIMIDINE-2,4-DIAMINO COMPOUNDS AND ANTIBODY CONJUGATES THEREOF. WO/2020/252043.

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