TLR7 agonist 22_product_DataBase

Bioactivity	TLR7 agonist 22 (Compound 11a) emerges as a selective TLR7 agonist with an IC50 value of 25.86 μM. TLR7 agonist 22 inhibits the cellular HBsAg secretion and effectively activates TLR7, thereby inducing the secretion of TLR7-regulated cytokines IL-12, TNF-αand IFN-αin human PBMC cells. TLR7 agonist 22 is a promising for research in the field of developing novel immunomodulatory anti-HBV agents[1].
Invitro	TLR7 agonist 22 (4 μM, 72h) 在 HepG2 细胞中抑制 HBV DNA 复制，其 IC50 值为 0.36 μM[1]。TLR7 agonist 22 (0.4, 2, 10 μM, 48 h) 具有 TLR7 激动效应，并有效增加 TLR7 诱导的 NF-κB 活性[1]。TLR7 agonist 22 (0.4, 2, 10 μM, 24 h) 剂量依赖性增强人类PBMC细胞中 IL-12、TNF-α 和 IFN-α 的产生[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> TLR7 agonist 22 相关抗体: Real Time qPCR[1] Cell Line:
In Vivo	TLR7 agonist 22 (10 MG/KG, i.g.) 在雄性 Sprague-Dawley 大鼠中具有相对适当的吸收时间和消除时间[1]。TLR7激动剂22的主要药代动力学参数[1]药代动力学分析[1]AUClast (h·ng/mL)
CAS	3036114-68-5
Formula	C20H17FN2O2S
Molar Mass	368.42
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Li S, et al. Exploration of 1-(indolin-1-yl)-2-(thiazol-2-yl)ethan-1-one derivatives as novel anti-HBV agent with potential TLR7 agonist 22onistic effect. Eur J Med Chem. 2024 Jun 8;275:116575.

PeptideDB

TLR7 agonist 22

CAS: 3036114-68-5 F: C20H17FN2O2S W: 368.42