| Bioactivity | TLR7 agonist 18 (Compound 21a) is a selective Toll-like receptor 7 (TLR7) agonist with an EC50 of 7.8 μM. TLR7 agonist 18 is not cytotoxic to hTLR7 cotransfected HEK293 cell lines and can induce the secretion of several cytokines, including IL-1β, IL-12p70, IL-8, and TNF-α. TLR7 agonist 18 can be used in vaccine, asthma, allergy and anti-cancer research[1]. |
| Target | EC50: 7.8 μM (TLR7). |
| Name | TLR7 agonist 18 |
| Formula | C18H16F4N4O |
| Molar Mass | 380.34 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Strašek Benedik N, et al. Structural Optimization and Biological Evaluation of Isoxazolo [5, 4-d] pyrimidines as Selective Toll-Like Receptor 7 Agonists[J]. ACS Omega, 2024. |