| Bioactivity | TLR4-IN-1 (compound 3k) inhibits the cell viability of RAW264.7 with an IC50 of 1.02 μM. TLR4-IN-1 inhibits the release of cytokine TNF-α, IL-1β and IL-6, and exhibits anti-inflammatory efficacy in rats rheumatoid arthritis models[1]. |
| CAS | 2617578-93-3 |
| Formula | C10H12O4 |
| Molar Mass | 196.20 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Zhou S, et al., Design, Synthesis, and Antirheumatoid Arthritis Mechanism of TLR4 Inhibitors. ACS Omega. 2024 Aug 14;9(34):36232-36241. |