THK-523

CAS: 1573029-17-0 F: C17H15FN2O W: 282.31

THK-523 has demonstrated its high affinity and selectivity for tau pathology both in vitro and in vivo. 18F-THK523 is a

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Bioactivity	THK-523 has demonstrated its high affinity and selectivity for tau pathology both in vitro and in vivo. 18F-THK523 is a potent tau imaging radiotracer. 18F-THK523 is a potent in vivo tau imaging ligand for Alzheimer's disease[1].
In Vivo	THK-523 crosses the blood–brain barrier in mice and the in vivo retention rate in the brain of Tau transgenic mice increased[1]. Animal Model:
Name	THK-523
CAS	1573029-17-0
Formula	C17H15FN2O
Molar Mass	282.31
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Ryuichi Harada, et al. Comparison of the binding characteristics of [18F]THK-523 and other amyloid imaging tracers to Alzheimer's disease pathology. Eur J Nucl Med Mol Imaging. 2013 Jan;40(1):125-32. [2]. Michelle T Fodero-Tavoletti, 18F-THK523: a novel in vivo tau imaging ligand for Alzheimer's disease. Brain. 2011 Apr;134(Pt 4):1089-100.