| Bioactivity | TH6342 is a SAMHD1 modulator that binds to pretetrameric SAMHD1 and prevents its oligomerization and allosteric activation. SAMHD1 is a dNTP triphosphohydrolase and an HIV-1 restriction factor. SAMHD1 can limit the replication of retroviruses and DNA viruses and has antiviral effects. The inhibitory mechanism of TH6342 does not occupy the SAMHD1 nucleotide-binding pocket, gently binds the target, and functions as a chemical probe[1]. |
| Invitro | TH6342 (2.5, 10, 40 μM) 以剂量依赖性方式阻碍 dGTP 诱导的 SAMHD1 激活 (IC50=9.1 μM)，在 0.05-0.5 mM 的浓度下也不改变 SAMHD1 对链霉蛋白酶处理的稳定性[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> TH6342 相关抗体: |
| Formula | C19H16ClN5 |
| Molar Mass | 349.82 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Zhang SM, et al. Identification and evaluation of small-molecule inhibitors against the dNTPase SAMHD1 via a comprehensive screening funnel. iScience. 2024 Jan 13;27(2):108907. |