| Bioactivity | TGFBR1-IN-2 (Compound AQA) is a TGFBR1 inhibitor and an antibacterial agent. TGFBR1-IN-2 is a substrate for cytochrome P450s. TGFBR1-IN-2 contains the pyridyl-6-methyl moiety necessary for Mycobacterium tuberculosis inhibition and has potent inhibitory activity against non-replicating and persistent Mycobacterium tuberculosis[1]. | ||||||||||||
| Invitro | TGFBR1-IN-2 对非复制的 Mycobacterium tuberculosis 具有抑菌效果, 其MIC90NR是 1 μM, MIC90是 20 μM, MIC50 是 16 μM[1]。TGFBR1-IN-2 (2-20 μM，35 天) 对药物耐受性微生物具有抑菌效果 (含有利福平 (HY-B0272) 和异烟肼 (HY-B0329) 的 Mycobacterium tuberculosis-GFP 培养物)[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> TGFBR1-IN-2 相关抗体: Cell Viability Assay[1] Cell Line: | ||||||||||||
| In Vivo | TGFBR1-IN-2 (10 mg/kg. p.o.) 在 CD1 小鼠体内的半衰期短，血浆浓度低，T1/2 为 1.8 h，Cmax 为 280 ng/mL，AUClast 为 640 h*ng/mL[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. | ||||||||||||
| CAS | 733806-89-8 | ||||||||||||
| Formula | C19H15N5 | ||||||||||||
| Molar Mass | 313.36 | ||||||||||||
| Appearance | 固体 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
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| Reference | [1]. Nandakumar, et al. Dual Inhibition of Mycobacterium tuberculosis and the Host TGFBR1 by an Anilinoquinazoline. Journal of medicinal chemistry. 2023, 66(21):14724-14734. |
TGFBR1-IN-2
CAS: 733806-89-8 F: C19H15N5 W: 313.36
TGFBR1-IN-2 (Compound AQA) is a TGFBR1 inhibitor and an antibacterial agent. TGFBR1-IN-2 is a substrate for cytochrome P
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