| Bioactivity | TG2-179-1 is a potent BAP1 inhibitor. TG2-179-1 inhibits the domain-containing deubiquitinase (DUB) activity of BAP1 by covalently binding to its active site. TG2-179-1 exerts cytotoxic activity, leading to defective replication and increased apoptosis. TG2-179-1 has the potential for colon cancer research[1]. |
| CAS | 1135023-19-6 |
| Formula | C22H14ClFN4O2S2 |
| Molar Mass | 484.95 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Minhwa Kang, et al. Targeting BAP1 with small compound inhibitor for colon cancer treatment. Sci Rep. 2023 Feb 8;13(1):2264. |
TG2-179-1
CAS: 1135023-19-6 F: C22H14ClFN4O2S2 W: 484.95
TG2-179-1 is a potent BAP1 inhibitor. TG2-179-1 inhibits the domain-containing deubiquitinase (DUB) activity of BAP1 by
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