| Bioactivity | TG 41 is positive modulator of GABAA receptor. TG 41 enhances the binding both of GABA and of Flunitrazepam to rat cerebral cortical membranes[1]. |
| Invitro | TG41 (0.001-10 µM) 增加特异性 [3H]GABA 与大鼠大脑皮质膜的结合[1]。TG41 (0.001-10 µM) 增加表达重组 α1β2γ2L GABAA 受体的蟾蜍卵母细胞中的内向 Cl- 电流[1]。 |
| In Vivo | TG 41 (5mg/kg, i.v.) 引起大鼠催眠[1]。 Animal Model: |
| Name | TG 41 |
| CAS | 850339-33-2 |
| Formula | C18H13BrCl2N2O2 |
| Molar Mass | 440.12 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Mascia MP, et al. Ethyl 2-(4-bromophenyl)-1-(2,4-dichlorophenyl)-1H-4-imidazolecarboxylate is a novel positive modulator of GABAA receptors. Eur J Pharmacol. 2005 Jun 15;516(3):204-11. |
TG 41
CAS: 850339-33-2 F: C18H13BrCl2N2O2 W: 440.12
TG 41 is positive modulator of GABAA receptor. TG 41 enhances the binding both of GABA and of Flunitrazepam to rat cereb
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