| Bioactivity | TFEB activator 3 (compound 45) exhibits more favorable TFEB activation and lysosome biogenesis capabilities. TFEB activator 3 has effect on TFEB nuclear translocation with 44% (10μM 3h) and 97 % (30 μM 3h). TFEB activator 3 plays an important role in Alzheimer’s disease (AD). TFEB activator 3 can pass blodd brain barrier[1]. |
| CAS | 3027413-48-2 |
| Formula | C20H20N2O2 |
| Molar Mass | 320.39 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Jianhui Zhou, et al. Discovery and Optimization of Tetrahydroisoquinoline Derivatives To Enhance Lysosome Biogenesis as Preclinical Candidates for the Treatment of Alzheimer’s Disease. J Med Chem. 2024 Jun 13;67(11):8836-8861. |
TFEB activator 3
CAS: 3027413-48-2 F: C20H20N2O2 W: 320.39
TFEB activator 3 (compound 45) exhibits more favorable TFEB activation and lysosome biogenesis capabilities. TFEB activa
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