| Bioactivity | TFEB activator 2 (compound 37) exhibits more favorable TFEB activation and lysosome biogenesis capabilities. TFEB activator 2 has effect on TFEB nuclear translocation with 72% (10μM 3h) and 94 % (30 μM 3h). TFEB activator 2 plays an important role in Alzheimer’s disease (AD). TFEB activator 2 can pass blood brain barrier[1]. |
| CAS | 3027414-04-3 |
| Formula | C26H29FN2O3 |
| Molar Mass | 436.52 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Jianhui Zhou, et al. Discovery and Optimization of Tetrahydroisoquinoline Derivatives To Enhance Lysosome Biogenesis as Preclinical Candidates for the Treatment of Alzheimer’s Disease. J Med Chem. 2024 Jun 13;67(11):8836-8861. |
TFEB activator 2
CAS: 3027414-04-3 F: C26H29FN2O3 W: 436.52
TFEB activator 2 (compound 37) exhibits more favorable TFEB activation and lysosome biogenesis capabilities. TFEB activa
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