| Bioactivity | TFE-IDAtp1-LinA is a highly potent amphiphilic carrier, containing a trifluoroethyl-iminodiacetic acid analog of Stp. TFE-IDAtp1-LinA,formed nanoparticles with Cas9 RNP/ssDNA, achieved enhanced green fluorescent protein knockouts with an ED50 of 0.38 nM Cas9/sgRNA ribonucleoproteins (RNP)[1]. |
| Sequence | {Lys(N3)}-Tyr-Tyr-Tyr-{TFE-IDAtp1}-{Lys(Lys(LinA)2)}-{TFE-IDAtp1}-Tyr-Tyr-Tyr |
| Shortening | {Lys(N3)}-YYY-{TFE-IDAtp}-{Lys(Lys(LinA)2)}-{TFE-IDAtp}-YYY |
| Formula | C136H204F6N26O22 |
| Molar Mass | 2669.23 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Yi Lin, et al. Chemical Evolution of Amphiphilic Xenopeptides for Potentiated Cas9 Ribonucleoprotein Delivery. J Am Chem Soc. 2023 Jul 19;145(28):15171-15179. |
TFE-IDAtp1-LinA
CAS: F: C136H204F6N26O22 W: 2669.23
TFE-IDAtp1-LinA is a highly potent amphiphilic carrier, containing a trifluoroethyl-iminodiacetic acid analog of Stp. TF
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