| Bioactivity | TET-13 is a positive allosteric modulator of GABAA receptor with an EC50 of 5.65 μM, lower than that of Etomidate (EC50: 9.29 μM). TET-13 shows potent anesthetic effects in both mice and rats (ED50: 0.48 mg/kg and 0.69 mg/kg, respectively)[1]. |
| Invitro | TET-13 (1 mg/mL, 0-30 min) 在 SD 大鼠血浆中代谢迅速，半衰期 T1/2 为 0.48 min[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> TET-13 相关抗体: |
| In Vivo | TET-13 (小鼠为 1.2 mg/kg, 大鼠为 1.725 mg/kg，静脉注射) 对小鼠和大鼠均表现出强效的麻醉作用 (ED50 分别为 0.48 mg/kg 和 0.69 mg/kg)，比依托咪酯更快恢复[1]。TET-13 (1.38 mg/kg, 静脉注射) 对大鼠血清皮质酮几乎无抑制作用，浓度为 970.12 nM[1]。TET 13 (22 mg/kg/h) 持续输注诱导大鼠 0.5、1 和 2 小时后的恢复时间和行走时间均短于依托咪酯[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: |
| Formula | C15H16N2O3S |
| Molar Mass | 304.36 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Zhu, et al. Discovery of thioetomidate derivatives as rapid recovery hypnotics without adrenocortical suppression. Bioorganic chemistry. 2024, 154, 107997. |