| Bioactivity | TERT activator-1 is a small molecule activator of telomerase reverse transcriptase (TERT). TERT activator-1 promotes TERT transcription through the MEK/ERK/AP-1 signaling cascade. TERT activator-1 promotes adult neurogenesis and enhances neuromuscular function. TERT activator-1 reduces cellular senescence and systemic inflammation in aged mice, and can be used in the study of aging[1]. | ||||||||||||
| Invitro | TERT activator-1 (0-10 μM；0-4 小时) 在 MRC-5 细胞中通过 MEK/ERK/AP-1 通路特异性激活 TERT 的转录，并可改变 TERT 启动子区域的染色质状态[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> TERT activator-1 相关抗体: Real Time qPCR[1] Cell Line: | ||||||||||||
| In Vivo | TERT activator-1 (6 mg/kg；腹腔注射；1-6 周) 在自然衰老小鼠中缓解衰老和促进成体神经发生[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: | ||||||||||||
| CAS | 666699-46-3 | ||||||||||||
| Formula | C14H12ClF2NO2S | ||||||||||||
| Molar Mass | 331.77 | ||||||||||||
| Appearance | 固体 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Shim HS, et al. TERT activation targets DNA methylation and multiple aging hallmarks. Cell. 2024 Jul 25;187(15):4030-4042.e13. |
TERT activator-1
CAS: 666699-46-3 F: C14H12ClF2NO2S W: 331.77
TERT activator-1 is a small molecule activator of telomerase reverse transcriptase (TERT). TERT activator-1 promotes TER
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