| Bioactivity | TEAD-IN-11 (compound 38) has a good inhibitory effect on TEAD1 (IC50=8.7 nM), TEAD2 (IC50=3.4 nM), TEAD3 (IC50=5.6 nnM). TEAD-IN-11 has good selective activity against TEAD1-3 as a covalent inhibitor. TEAD-IN-11 can be used for cancer research[1]. |
| Invitro | TEAD-IN-11 对 MCF-7 报告基因试验有较好的抑制作用 (IC50≤10 nM) [1]。TEAD-IN-11 对 TEAD1 和 TEAD2 具有很好的选择性，在 HEK293T 细胞中分别有 93% 和 95% 的抑制效果[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> TEAD-IN-11 相关抗体: Cell Viability Assay[1] Cell Line: |
| CAS | 3032196-88-3 |
| Formula | C16H14F3NO |
| Molar Mass | 293.28 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Henry William, et al. Yap/taz-tead oncoproteins inhibitors.WO2024059317A1.2023-09-15 |
TEAD-IN-11
CAS: 3032196-88-3 F: C16H14F3NO W: 293.28
TEAD-IN-11 (compound 38) has a good inhibitory effect on TEAD1 (IC50=8.7 nM), TEAD2 (IC50=3.4 nM), TEAD3 (IC50=5.6 nnM).
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