| Bioactivity | TEAD-IN-1 (Compound 2) is potent TEAD autopalmitoylation inhibitor, with an IC50 of 603 nM. TEAD-IN-1 increases the interaction of TEAD and VGLL4. TEAD-IN-1 decreases the interaction of YAP and TEAD. TEAD-IN-1 can be used for the research of cancer[1][2]. |
| CAS | 2412761-57-8 |
| Formula | C15H20F2N2O3S |
| Molar Mass | 346.39 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Holden JK, et al. Small Molecule Dysregulation of TEAD Lipidation Induces a Dominant-Negative Inhibition of Hippo Pathway Signaling. Cell Rep. 2020 Jun 23;31(12):107809. [2]. Guarnaccia A D, et al. TEAD-targeting small molecules induce a cofactor switch to regulate the Hippo pathway. bioRxiv, 2024: 2024.11. 15.623512. |
TEAD-IN-1
CAS: 2412761-57-8 F: C15H20F2N2O3S W: 346.39
TEAD-IN-1 (Compound 2) is potent TEAD autopalmitoylation inhibitor, with an IC50 of 603 nM. TEAD-IN-1 increases the inte
Sales Email：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.