| Bioactivity | TDP1 Inhibitor-2 (compound 5) is a potent inhibitor for TDP1 (tyrosyl-DNA phosphodiesterase 1), with an IC50 of 99 nM. TDP1 Inhibitor-2 also can inhibit SCAN1 (spinocerebellar ataxia syndrome with axonal neuropathy), with an IC50 of 3.5 μM[1]. |
| Target | IC50: 0.099 ± 0.044 μM (TDP1), 3.5 ± 2.3 μM (SCAN1) |
| Invitro | TDP1 Inhibitor-2 (compound 5) shows potent anti-TDP1 activity, low cytotoxicity and synergism with topotecan, an established Top1 anticancer agent[1]. |
| Name | TDP1 Inhibitor-2 |
| CAS | 859142-95-3 |
| Formula | C25H14Cl2O5 |
| Molar Mass | 465.28 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Mamontova EM, et al. Identification of novel inhibitors for the tyrosyl-DNA-phosphodiesterase 1 (Tdp1) mutant SCAN1 using virtual screening. Bioorg Med Chem. 2020 Jan 1;28(1):115234. |
TDP1 Inhibitor-2
CAS: 859142-95-3 F: C25H14Cl2O5 W: 465.28
TDP1 Inhibitor-2 (compound 5) is a potent inhibitor for TDP1 (tyrosyl-DNA phosphodiesterase 1), with an IC50 of 99 nM. T
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