| Bioactivity | TDI-10229 is a potent and orally bioavailable inhibitor of soluble adenylyl cyclase (sAC, ADCY10). TDI-10229 displays nanomolar inhibition of sAC in both biochemical and cellular assays (IC50 of 195 nM) and exhibits mouse pharmacokinetic properties sufficient to warrant its use as an in vivo tool compound[1][2]. | ||||||||||||
| Target | IC50: 195 nM (sAC). | ||||||||||||
| Invitro | TDI-10229 exhibits good permeability with an IC50 of 92 nM for human 4-4 cells[2]. | ||||||||||||
| In Vivo | TDI-10229 (5 mg/kg; p.o.) treatment shows the Cmax, AUC and MRT were 15.5 μM, 94 μg h/mL and 3.95 hours, respectively. Animal Model: | ||||||||||||
| Name | TDI-10229 | ||||||||||||
| CAS | 2810887-45-5 | ||||||||||||
| Formula | C16H16ClN5 | ||||||||||||
| Molar Mass | 313.78 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
|
||||||||||||
| Reference | [1]. Balbach M, et al. Soluble adenylyl cyclase inhibition prevents human sperm functions essential for fertilization [published online ahead of print, 2021 Aug 31]. Mol Hum Reprod. 2021;gaab054. [2]. Fushimi M, et al. Discovery of TDI-10229: A Potent and Orally Bioavailable Inhibitor of Soluble Adenylyl Cyclase (sAC, ADCY10). ACS Med Chem Lett. 2021;12(8):1283-1287. Published 2021 Jul 14. |
TDI-10229
CAS: 2810887-45-5 F: C16H16ClN5 W: 313.78
TDI-10229 is a potent and orally bioavailable inhibitor of soluble adenylyl cyclase (sAC, ADCY10). TDI-10229 displays na
Sales Email：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.