| Bioactivity | TCS1105 is a benzodiazepine ligand with agonist for α2-subunit containing GABAA receptors and antagonist for α1-subunit containing GABAA receptors. TCS1105 reduces anxiety-like behavior in mice. TCS1105 enhances offensive behavior and social dominance. TCS1105 blocks Sema3A induced AGC (axonal growth cones) collapse in a concentration-dependent fashion[1][2]. |
| Name | TCS1105 |
| CAS | 185391-33-7 |
| Formula | C17H13FN2O2 |
| Molar Mass | 296.30 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. van der Kooij MA, et al. GABAA receptors in the ventral tegmental area control the outcome of a social competition in rats. Neuropharmacology. 2018 Aug;138:275-281. [2]. Xu J, et al. Anesthetics disrupt growth cone guidance cue sensing through actions on the GABAA α2 receptor mediated by the immature chloride gradient. Neurotoxicol Teratol. 2019 Jul-Aug;74:106812. |