| Bioactivity | TCS PrP Inhibitor 13, an antiprion agent, is a cellular prion protein (PrPC) inhibitor. TCS PrP Inhibitor 13, as a protease-resistant form of prion protein (PrP-res) accumulation inhibitor, shows an IC50 value of 3 nM in both ScN2a and F3 cell lines. TCS PrP Inhibitor 13 induces Schwannoma cells apoptosis[1]. | ||||||||||||
| Invitro | TCS PrP Inhibitor 13 (0~500 μM; Schwannoma cells) significantly reduces levels of total ERK1/2, pAKT, total FAK, Cyclin D1, PrPC and significantly increases expression of cleaved caspase-3. TCS PrP Inhibitor 13 (Schwannoma cells) significantly reduces the number of proliferating, Ki67-positive cells and total cell number[2]. | ||||||||||||
| Name | TCS PrP Inhibitor 13 | ||||||||||||
| CAS | 34320-83-7 | ||||||||||||
| Formula | C15H11N3O3 | ||||||||||||
| Molar Mass | 281.27 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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TCS PrP Inhibitor 13
CAS: 34320-83-7 F: C15H11N3O3 W: 281.27
TCS PrP Inhibitor 13, an antiprion agent, is a cellular prion protein (PrPC) inhibitor. TCS PrP Inhibitor 13, as a prote
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