| Bioactivity | TC-E 5003 is a selective PRMT1 inhibitor with an IC50 of 1.5 µM against hPRMT1. TC-E 5003 has anti-inflammatory properties in TLR4 signaling[1][2]. | ||||||||||||
| Name | TC-E 5003 | ||||||||||||
| CAS | 17328-16-4 | ||||||||||||
| Formula | C16H14Cl2N2O4S | ||||||||||||
| Molar Mass | 401.26 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
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| Reference | [1]. Bissinger EM, et al. Acyl derivatives of p-aminosulfonamides and dapsone as new inhibitors of the arginine methyltransferase hPRMT1. Bioorg Med Chem. 2011;19(12):3717-3731. [2]. Kim E, et al. Protein Arginine Methyltransferase 1 (PRMT1) Selective Inhibitor, TC-E 5003, Has Anti-Inflammatory Properties in TLR4 Signaling. Int J Mol Sci. 2020;21(9):3058. Published 2020 Apr 26. |
TC-E 5003
CAS: 17328-16-4 F: C16H14Cl2N2O4S W: 401.26
TC-E 5003 is a selective PRMT1 inhibitor with an IC50 of 1.5 µM against hPRMT1. TC-E 5003 has anti-inflammatory propert
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