TC-2153_product_DataBase

Bioactivity	TC-2153 is a selective inhibitor of striatal-enriched protein tyrosine phosphatase (STEP), with psychotropic activity and low acute toxicity. TC-2153 increases the expression of brain-derived neurotropic factor (BDNF) in the brain. And it decreases MAOA and 5-HT1A receptors mRNA level in midbrain. TC-2153 also inhibits 5-HT2A receptor-mediated signaling[1].
Invitro	TC-2153 (10 μM; 3 h) 减少皮层和海马神经元体外培养中 DOI (HY-103124) 诱导的 c-fos 阳性神经元百分比[1]。
In Vivo	慢性 TC-2153 处理: TC-2153 (20 mg/kg; 腹腔注射; 每天 1 次，连续 7 天) 显示抗抑郁类效果，不改变运动，探索活动和焦虑情况[1]。急性 TC-2153 处理: TC-2153 (10 mg/kg和20 mg/kg; 单次剂量) 抑制小鼠体内 5-HT2A 受体的功能活性[1]。 Animal Model:
Name	TC-2153
CAS	1381769-23-8
Formula	C7H5ClF3NS5
Molar Mass	355.89
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Walters JM, et al. Pharmacological inhibition of STriatal-Enriched protein tyrosine Phosphatase by TC-2153 reduces hippocampal excitability and seizure propensity. Epilepsia. 2022 May;63(5):1211-1224.

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