| Bioactivity | TAX2 peptide is a dodecapeptide based on molecular docking and simulation design, derived from the cell surface receptor CD47 sequence. TAX2 peptide acts as a selective antagonist of TSP-1 (thromboxin-1) interacting with CD47. TAX2 peptide can promote the binding of TSP-1 to CD36, which leads to the destruction of VEGFR2 (vascular endothelial growth factor receptor 2) activation, thereby blocking downstream NO (nitric oxide) signaling, demonstrating anti-angiogenic properties. TAX2 peptide can be used to study angiogenesis and tumor cell interactions in the tumor microenvironment[1]. |
| Sequence | Cys-Glu-Val-Ser-Gln-Leu-Leu-Lys-Gly-Asp-Ala-Cys (Disulfide bridge: Cys1-Cys12) |
| Shortening | CEVSQLLKGDAC (Disulfide bridge: Cys1-Cys12) |
| Formula | C51H86N14O19S2 |
| Molar Mass | 1263.44 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Jeanne A, et al. Identification of TAX2 peptide as a new unpredicted anti-cancer agent[J]. Oncotarget, 2015, 6(20): 17981. |