TAT-N15_product_DataBase

Bioactivity	TAT-N15 is a p55PIK inhibitor with remarkable anti-inflammatory activity and neuroprotective effects. TAT-N15 can significantly inhibit the activation of IL-6, IL-8, Akt, and NF-κB pathways, as well as suppress the protein expression of phosphorylated STAT3 and NF-κB. By inhibiting the activation of Akt, STAT3, and NF-κB pathways, TAT-N15 is used in research on acute conjunctivitis, allergic rhinitis, chronic obstructive pulmonary disease (COPD), and stroke[1][2].
CAS	2415370-74-8
Sequence	Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Met-Met-Pro-Tyr-Ser-Thr-Glu-Leu-Ile-Phe-Tyr-Ile-Glu-Met-Asp-Pro
Shortening	YGRKKRRQRRRMMPYSTELIFYIEMDP
Formula	C155H250N48O40S3
Molar Mass	3522.14
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Liu Y, et al. A novel p55PIK signaling peptide inhibitor alleviates neuroinflammation via the STAT3/NF-kB signaling pathway in experimental stroke[J]. Journal of Stroke and Cerebrovascular Diseases, 2024, 33(7): 107736. [2]. Wang T, et al. p55PIK deficiency and its NH2-terminal derivative inhibit inflammation and emphysema in COPD mouse model[J]. American Journal of Physiology-Lung Cellular and Molecular Physiology, 2021, 321(1): L159-L173.

PeptideDB