TAT-GluN2BCTM_product_DataBase

Bioactivity	TAT-GluN2BCTM is a membrane-permeable DAPK1-targeting peptide. TAT-GluN2BCTM targets active DAPK1 to lysosomes for degradation. TAT-GluN2BCTM protects neurons from oxidative stress and NMDAR-mediated excitotoxicity by knocking down DAPK1. TAT-GluN2BCTM can be used in the study of neuroprotection[1].
Target	DAPK1.
Invitro	TAT-GluN2BCTM (200 µM; 0.5, 2, 4 h) 以时间依赖性的方式降低 NMDA 处理的原代神经元培养物中 DAPK1 的水平[1]。 Western Blot Analysis[1] Cell Line:
In Vivo	TAT-GluN2BCTM (10 mg/kg; i.v.; single) 导致大鼠大脑缺血侧的 DAPK1 水平显着降低[1]。TAT-GluN2BCTM (10 mg/kg; i.v.; single) 在大鼠的皮质和纹状体中显示出显着的神经保护作用[1]。TAT-GluN2BCTM 能够特异性敲低 DAPK1 的活性（但不是非活性）形式[1]。 Animal Model:
Name	TAT-GluN2BCTM
CAS	1587742-50-4
Sequence	Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Lys-Lys-Asn-Arg-Asn-Lys-Leu-Arg-Arg-Gln-His-Ser-Tyr-Lys-Phe-Glu-Arg-Gln-Lys-Ile-Leu-Asp-Gln-Arg-Phe-Phe-Glu
Shortening	YGRKKRRQRRRKKNRNKLRRQHSYKFERQKILDQRFFE
Formula	C224H374N86O54
Molar Mass	5135.91
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Fan X, et al. Rapid and reversible knockdown of endogenous proteins by peptide-directed lysosomal degradation. Nat Neurosci. 2014 Mar;17(3):471-80.

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