| Bioactivity | TASK-1-IN-1 is a potent and selective TASK-1 (Potassium Channel)?inhibitor with an IC50 of 148 nM. TASK-1-IN-1 shows a reduced inhibition of TASK-3 channels (IC50 of 1750 nM) and not a significant effect on other K+ channels. TASK-1-IN-1 has anticancer effects[1]. |
| Target | IC50: 148 nM (TASK-1) and 1750 nM (TASK-3) |
| Invitro | TASK-1-IN-1 (compound F3) blocks cell proliferation and viability in the MCF-7 cancer cell line but not in TASK-1 knockdown MCF-7 cells, indicating that it is acting in TASK-1 channels[1]. Cell Proliferation Assay[1] Cell Line: |
| Name | TASK-1-IN-1 |
| CAS | 600125-11-9 |
| Formula | C22H20N2O2 |
| Molar Mass | 344.41 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Bárbara Arévalo, et al. Selective TASK-1 Inhibitor with a Defined Structure-Activity Relationship Reduces Cancer Cell Proliferation and Viability. J Med Chem. 2022 Nov 24;65(22):15014-15027. |
TASK-1-IN-1
CAS: 600125-11-9 F: C22H20N2O2 W: 344.41
TASK-1-IN-1 is a potent and selective TASK-1 (Potassium Channel)?inhibitor with an IC50 of 148 nM. TASK-1-IN-1 shows a r
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