| Bioactivity | TA-3166 (Megakaryocytes/platelets inducing agent) is a novel chemically synthesized c-MPL agonist (CMA) and thrombopoietin (TPO) receptor agonist. TA-316 enhances ex vivo platelet generation from human-induced pluripotent stem (iPS) cells[1][2]. | ||||||||||||
| Invitro | TA-316 (0.01-1000 nM; 4 days) stimulates UT-7/TPO and Ba/F3-HuMpl cells proliferation, with the EC50 values of 0.3 and 0.65 nM, respectively[2].TA-316 (800 nM; 10 days) promotes biased megakaryopoiesis and upregulated MK lineage markers[2].TA-316 (200 nM; 4 days) preferentially enhances VEGFA and FGF2 expression[2]. Cell Viability Assay[2] Cell Line: | ||||||||||||
| Name | TA-316 | ||||||||||||
| CAS | 1429321-13-0 | ||||||||||||
| Formula | C28H25BrN4O5S2 | ||||||||||||
| Molar Mass | 641.56 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. METHOD FOR PRODUCING MEGAKARYOCYTES AND/OR PLATELETS FROM PLURIPOTENT STEM CELLS.WO2013051625A1. [2]. Aihara A, et al. Novel TPO receptor agonist TA-316 contributes to platelet biogenesis from human iPS cells. Blood Adv. 2017;1(7):468-476. Published 2017 Feb 28. |
TA-316
CAS: 1429321-13-0 F: C28H25BrN4O5S2 W: 641.56
TA-3166 (Megakaryocytes/platelets inducing agent) is a novel chemically synthesized c-MPL agonist (CMA) and thrombopoiet
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