| Bioactivity | T-518 is an orally active, selective, and blood-brain barrier permeable HDAC6 inhibitor with an IC50 value of 36 nM for human HDAC6. T-581 can be used in research on Alzheimer's disease and tauopathy[1]. |
| CAS | 2276680-91-0 |
| Formula | C19H16F7N5O3 |
| Molar Mass | 495.35 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Onishi T, et al. A novel orally active HDAC6 inhibitor T-518 shows a therapeutic potential for Alzheimer's disease and tauopathy in mice. Sci Rep. 2021 Jul 29;11(1):15423. [2]. König B, et al. 2-(Difluoromethyl)-1, 3, 4-oxadiazoles: The Future of Selective Histone Deacetylase 6 Modulation?[J]. ACS Pharmacology & Translational Science, 2024. |