T-1101 tosylate_product_DataBase

Bioactivity	T-1101 tosylate (TAI-95 tosylate) is a Hec1/Nek2 (Highly expressed in cancer 1 / NIMA-related kinase 2) inhibitor with antitumor activity. T-1101 tosylate is inactive toward normal cells, kinases and hERG[1]
Invitro	T-1101 tosylate shows potent in vitro antiproliferative activity (IC50: 14.8-21.5 nM)[1].T-1101 tosylate disrupts the Hec1/Nek2 protein–protein interaction in the cells[1].T-1101 tosylate (1μM; 3-24 24 hours) decreases the level of Nek2 in a time-dependent manner[1].T-1101 tosylate (1 µM; 24 hours) induces apoptosis[1].T-1101 tosylate reduces amounts of cell-cycle related proteins cyclin A1, cyclin B1, and cyclin D1[1]. Apoptosis Analysis[1] Cell Line:
Name	T-1101 tosylate
CAS	2250404-95-4
Formula	C31H31N5O6S3
Molar Mass	665.80
Transport	Room temperature in continental US; may vary elsewhere.
Storage	4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

PeptideDB