T-1-PMPA_product_DataBase

Bioactivity	T-1-PMPA is a potent EGFR inhibitor with apoptotic properties. T-1-PMPA effectively inhibits EGFRWT and EGFR790m, with IC50 values of 86 nM and 561.73 nM, respectively[1].
Invitro	T-1-PMPA (0.312-10 μM; 24 h) 可显着抑制 HepG2 和 MCF7 恶性细胞系的增殖，IC50 值分别为 3.51 μM 和 4.13 μM[1]。在 HepG2 细胞中，T-1-PMPA 使凋亡早期细胞比例从 0.77% 增加到 29.17%，凋亡晚期细胞比例从 0.17% 增加到 8.81%，整体细胞比例从 3.05% 增加到 42.03%。此外，与对照细胞的 2.21% 相比，坏死细胞的百分比增加至 4.05%。qRT-PCR 分析显示 caspase-3 和 caspase-9 水平显着增加，进一步支持了细胞凋亡效应。T-1-PMPA 将 TNFα 和 IL2 水平分别控制 74% 和 50%[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> T-1-PMPA 相关抗体: Cell Viability Assay[1] Cell Line:
CAS	1323883-62-0
Formula	C16H17N5O3
Molar Mass	327.34
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Ibrahim H Eissa, et al. New Theobromine Apoptotic Analogue with Anticancer Potential Targeting the EGFR Protein: Computational and In Vitro Studies. ACS Omega. 2024 Mar 27;9(14):15861-15881.

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