Syk Inhibitor II dihydrochloride_product_DataBase

Bioactivity	Syk Inhibitor II dihydrochloride is a potent, high selective and ATP-competitive Syk inhibitor with an IC50 of 41 nM. Syk Inhibitor II dihydrochloride inhibits 5-HT release from RBL-cells with an IC50 of 460 nM. Syk Inhibitor II dihydrochloride shows less potent against other kinases and has anti-allergic effect[1].
Invitro	Syk Inhibitor II (compound 9a) dihydrochloride 对 PKCε、PKCβ2、ZAP-70、Btk 和 Itk 的作用较弱，IC50 值分别为 5.1 µM、11 µM、11.2 µM、15.5 µM 和 22.6 µM[1]。
In Vivo	Syk Inhibitor II (Compound 9a; 10-100 mg/kg) dihydrochloride 在抗原攻击前 30 分钟皮下给药，以剂量依赖方式抑制过敏反应，ID50 值为13.2 mg/kg[1]。 Animal Model:
Name	Syk Inhibitor II dihydrochloride
CAS	227449-73-2
Formula	C14H17Cl2F3N6O
Molar Mass	413.23
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Hiroyuki Hisamichi, et al. Synthetic studies on novel Syk inhibitors. Part 1: Synthesis and structure-activity relationships of pyrimidine-5-carboxamide derivatives. Bioorg Med Chem. 2005 Aug 15;13(16):4936-51.

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