Suprafenacine_product_DataBase

Bioactivity	Suprafenacine is a cell permeable, tubulin-destabilizing molecule which bind microtubules at the colchicine-binding site and inhibit polymerization. Suprafenacine can induce G2/M cell cycle arrest and apoptosis, and can be used for cancer research[1].
Invitro	Suprafenacine (10 μM, 24 h) 使 G1 期的 Hela 细胞完全停滞，并增加 G2/M 期细胞数量，而预处理 7 h 则诱导增殖的 Hela 细胞发生凋亡[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> Suprafenacine 相关抗体:
In Vivo	Suprafenacine (20 mg/kg, 腹腔注射，每 3 天 1 次，共 9 天) 与对照组小鼠相比，抑制 HCT15 荷瘤 SCID 小鼠 40% 的肿瘤质量[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only.
CAS	1477482-50-0
Formula	C16H18N4O
Molar Mass	282.34
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Choi BH, et al. Suprafenacine, an indazole-hydrazide agent, targets cancer cells through microtubule destabilization. PLoS One. 2014 Oct 29;9(10):e110955.

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