PeptideDB

Sulfo-ara-F-NMN

CAS: 1374663-29-2 F: C11H14FN2O6PS W: 352.28

Sulfo-ara-F-NMN (CZ-48) is a mimetic of nicotinamide mononucleotide (NMN). Sulfo-ara-F-NMN acts selectively, activating
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This product is for research use only, not for human use. We do not sell to patients.

Bioactivity Sulfo-ara-F-NMN (CZ-48) is a mimetic of nicotinamide mononucleotide (NMN). Sulfo-ara-F-NMN acts selectively, activating SARM1 but inhibiting CD38 (IC50 around 10 μM). Sulfo-ara-F-NMN induces intracellular cyclic ADP-ribose (cADPR) production[1].
Invitro Sterile alpha and Toll/interleukin-1 receptor motif-containing 1 (SARM1) is an adaptor protein in the Toll-like receptor pathway. Sulfo-ara-F-NMN activates SARM1 to produce cyclic ADP-ribose and induces non-apoptotic cell death[1].
Name Sulfo-ara-F-NMN
CAS 1374663-29-2
Formula C11H14FN2O6PS
Molar Mass 352.28
Appearance Solid
Transport Room temperature in continental US; may vary elsewhere.
Storage

-20°C, stored under nitrogen

*该产品在溶液状态不稳定,建议您现用现配,即刻使用。

Reference [1]. Zhao ZY, et al. A Cell-Permeant Mimetic of NMN Activates SARM1 to Produce Cyclic ADP-Ribose and Induce Non-apoptotic Cell Death. iScience. 2019 May 31;15:452-466.