| Bioactivity | Sulcardine hydrochloride is a multi-ion channel blocker that can reduce INa and ICa with IC50 values of 26.9 µM and 69.2 µM, respectively. Sulcardine hydrochloride is a potent hNav1.5 channel blocker with a mild inhibitory effect on hERG channels. Sulcardine hydrochloride has anti-arrhythmic effects[1][2]. |
| Target | IC50: 26.9 µM (INa).IC50: 69.2 µM (ICa). |
| CAS | 343935-48-8 |
| Formula | C24H35Cl2N3O4S |
| Molar Mass | 532.52 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. BaiDL,et al. Discovery ofN-(3,5-bis(1-pyrrolidylmethyl)-4-hydroxybenzyl)-4-methoxybenzenesulfamide(sulcardine) as a novel anti-arrhythmic agent. Acta Pharmacol Sin. 2012Sep;33(9):1176-86. [2]. Chen W, et al. Characteristics of hERG and hNav1.5 channel blockade by sulcardine sulfate, a novel anti-arrhythmic compound. Eur J Pharmacol. 2019 Feb 5;844:130-138. |
Sulcardine hydrochloride
CAS: 343935-48-8 F: C24H35Cl2N3O4S W: 532.52
Sulcardine hydrochloride is a multi-ion channel blocker that can reduce INa and ICa with IC50 values of 26.9 µM and 69.
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