| Bioactivity | Suffruticosol A is a neuroprotective agent that restores scopolamine-induced cellular neurodegenerative damage. Suffruticosol A ameliorates hippocampal cholinergic deficits and partially enhances BDNF signaling. Suffruticosol A has neuromodulatory effects in a Scopolamine (HY-N0296)-induced model, restoring memory and cognitive performance in mice. Suffruticosol A can be isolated from seeds of P. lactiflora[1]. |
| Target | BDNF |
| Invitro | Suffruticosol A（20 μM；24 小时）可恢复人神经母细胞瘤 SH-SY5Y 细胞相对东莨菪碱 (2 mM) 处理的细胞活力和存活率[1]。 0 --> Suffruticosol A 相关抗体: |
| In Vivo | Suffruticosol A（4 或 15 ng，每周两次；注射到大脑第三脑室）可改善东莨菪碱 (1.0 mg/kg；腹腔注射) 引起的小鼠模型认知和记忆损伤的神经元效应[1]。 |
| Name | Suffruticosol A |
| Formula | C42H34O9 |
| Molar Mass | 682.71 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Kim JH, et al. Enhanced neuronal activity by suffruticosol A extracted from Paeonia lactiflora via partly BDNF signaling in scopolamine-induced memory-impaired mice. Sci Rep. 2023 Jul 20;13(1):11731. |