| Bioactivity | Sucunamostat hydrate (SCO-792) is an orally active and reversible enteropeptidase inhibitor with IC50s of 4.6 nM and 5.4 nM for rat enteropeptidase and human enteropeptidase, respectively. Sucunamostat hydrate can slowly dissociate from enteropeptidase in vitro and inhibit protein digestion in vivo[1]. |
| Target | IC50: 4.6 nM (rat enteropeptidase), 5.4 nM (human enteropeptidase) |
| In Vivo | Sucunamostat hydrate (10 和 30 mg/kg；口服，单次剂量) 有效且剂量依赖性地抑制大鼠口服蛋白质剂量诱导的血浆支链氨基酸 (BCAA) 升高[1]。Sucunamostat hydrate 在雄性 Sprague-Dawley 大鼠体内的药代动力学参数[1] |
| Name | Sucunamostat hydrate |
| Formula | C22H22N4O8.xH2O |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Sasaki M, et al. Discovery and characterization of a small-molecule enteropeptidase inhibitor, SCO-792. Pharmacol Res Perspect. 2019 Sep 4;7(5):e00517. |