Succinyl-(Pro58,D-Glu65)-Hirudin (56-65) (sulfated)_product_DataBase

Bioactivity	Succinyl-(Pro58,D-Glu65)-Hirudin (56-65) (sulfated) is a hirugen-like peptide, and has high affnity for thrombin than Hirugen, with a KD < 100 nM. Succinyl-(Pro58,D-Glu65)-Hirudin (56-65) (sulfated) is an antithrombotic agent. Succinyl-(Pro58,D-Glu65)-Hirudin (56-65) (sulfated) inhibits the thrombin-induced fibrin clot formation with an IC50 value of 0.087 μM[1].
Name	Succinyl-(Pro58,D-Glu65)-Hirudin (56-65) (sulfated)
CAS	131791-98-5
Sequence	{Suc-Phe}-Glu-Pro-Ile-Pro-Glu-Glu-{Tyr(SO3H)}-Leu-{d-Glu}
Shortening	{Suc-Phe}-EPIPEE-{Tyr(SO3H)}-L-{d-Glu}
Formula	C64H88N10O26S
Molar Mass	1445.50
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Dekker RJ, et al. The variable region-1 from tissue-type plasminogen activator confers specificity for plasminogen activator inhibitor-1 to thrombin by facilitating catalysis: release of a kinetic block by a heterologous protein surface loop. J Mol Biol. 1999 Oct 29;293(3):613-27. [2]. Payne MH, et al. Positional effects of sulfation in hirudin and hirudin PA related anticoagulant peptides. J Med Chem. 1991 Mar;34(3):1184-7.

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