Substance P (6-11)_product_DataBase

Bioactivity	Substance P (6-11) is the C-terminal hexapeptideamide of Substance P (Substance P (HY-P0201)). Substance P (6-11) binds to NK-1 tachykinin receptor. Substance P (6-11) shows depolarization of motoneurons and a hypotensive effect[1][2].
Invitro	Substance P(6-11) 在大鼠膀胱中刺激 [3H]-肌醇一磷酸 ([3H]-IP1) 的形成，EC50 值为 4 nM。
In Vivo	Substance P (6-11) (0.1-10 nM) 以剂量依赖的方式抑制大鼠胰腺分泌胰岛素和胰高血糖素。相反，在犬胰腺中，Substance P (6-11) (1-10 nM) 会增强胰岛素、胰高血糖素和生长抑素的释放[2]。
Name	Substance P (6-11)
CAS	51165-07-2
Shortening	QFFGLM-NH2
Formula	C36H52N8O7S
Molar Mass	740.91
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Y Torrens, et al. Substance P(6-11) and natural tachykinins interact with septide-sensitive tachykinin receptors coupled to a phospholipase C in the rat urinary bladder. Neuropeptides. 1997 Jun;31(3):243-51. [2]. Y Chiba, et al. Effects of substance P and substance P-(6-11) on hormone release from isolated perfused pancreas: their opposite actions on rat and canine islets. Endocrinology. 1985 Nov;117(5):1996-2000.

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