| Bioactivity | Stigmasterol is a plant sterol which has been focused on the cholesterol-lowering activity and is valued as an anti-stiffness factor in the therapy of rheumatic diseases. | ||||||||||||
| Invitro | Preincubation of Stigmasterol to IL-1beta-treated cells shows significant reduction of MMP-3 mRNA in human and mouse, MMP-3 protein in mouse, MMP-13 mRNA in mouse and human, ADAMTS-4 mRNA in human, PGE2 protein in human and mouse. Stigmasterol is also capable of counteracting the IL-1beta-induced NF-κB pathway[1]. | ||||||||||||
| Name | Stigmasterol | ||||||||||||
| CAS | 83-48-7 | ||||||||||||
| Formula | C29H48O | ||||||||||||
| Molar Mass | 412.69 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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