Steroid sulfatase/17β-HSD1-IN-4_product_DataBase

Bioactivity	Steroid sulfatase/17β-HSD1-IN-4 (compound 37) is a dual inhibitor of steroid sulfatase (STS) and 17β-hydroxysteroid dehydrogenase type 1 (17β HSD1). Steroid sulfatase/17β-HSD1-IN-4 irreversibly inhibits hSTS activity with anIC50 value of 63 nM. Steroid sulfatase/17β-HSD1-IN-4 can be used in the study of endometriosis and other estrogen-dependent diseases[1].
Target	IC50: 63 nM (hSTS).
Invitro	Steroid sulfatase/17β-HSD1-IN-4 (compound 37) (0-1100 nM, 24 h) inhibits human steroid sulfatase (hSTS) with an IC50 value of 63 nM and acts on irreversible inhibition of hSTS with an IC50 value of 60 nM in T47D human breast cancer cells[1].Steroid sulfatase/17β-HSD1-IN-4 (compound 37) (20 μM, 48 h) inhibits HEK-293 cells growth by 15.1% at a concentration of 20 μM with low cytotoxicity[1].
Name	Steroid sulfatase/17β-HSD1-IN-4
Formula	C18H17N3O4S2
Molar Mass	403.48
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Abdelrahman Mohamed, et al. Dual Targeting of Steroid Sulfatase and 17β-Hydroxysteroid Dehydrogenase Type 1 by a Novel Drug-Prodrug Approach: A Potential Therapeutic Option for the Treatment of Endometriosis. J Med Chem. 2022 Aug 22.

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