Steroid sulfatase/17β-HSD1-IN-3_product_DataBase

Bioactivity	Steroid sulfatase/17β-HSD1-IN-3 (compound 19) is a dual inhibitor of steroid sulfatase (STS) and 17β-hydroxysteroid dehydrogenase type 1 (17β HSD1). Steroid sulfatase/17β-HSD1-IN-3 irreversibly inhibits hSTS activity with anIC50 value of 27 nM. Steroid sulfatase/17β-HSD1-IN-3 can be used in the study of endometriosis and other estrogen-dependent diseases[1].
Target	IC50: 27 nM (hSTS).
Invitro	Steroid sulfatase/17β-HSD1-IN-3 (compound 19) (0-1100 nM, 24 h) inhibits human steroid sulfatase (hSTS) with an IC50 value of 27 nM and acts on irreversible inhibition of hSTS with an IC50 value of 29 nM in T47D human breast cancer cells[1].Steroid sulfatase/17β-HSD1-IN-3 (compound 19) (20 μM, 48 h) inhibits HEK-293 cells growth by 30% at a concentration of 20 μM with low cytotoxicity[1].
Name	Steroid sulfatase/17β-HSD1-IN-3
Formula	C19H17ClN2O5S
Molar Mass	420.87
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Abdelrahman Mohamed, et al. Dual Targeting of Steroid Sulfatase and 17β-Hydroxysteroid Dehydrogenase Type 1 by a Novel Drug-Prodrug Approach: A Potential Therapeutic Option for the Treatment of Endometriosis. J Med Chem. 2022 Aug 22.

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