Steroid sulfatase/17β-HSD1-IN-1_product_DataBase

Bioactivity	Steroid sulfatase/17β-HSD1-IN-1 is a potent steroid sulfatase and 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1) inhibitor with an IC50 value of 28 nM for cellular human steroid sulfatase. Steroid sulfatase/17β-HSD1-IN-1 can be used to research estrogen-dependent diseases[1].
Target	IC50: 28 nM (cellular human steroid sulfatase)
Invitro	Steroid sulfatase/17β-HSD1-IN-1 (compound 13) (20 μM; 48 h) has a low cytotoxicity in HEK-293 cells[1].Steroid sulfatase/17β-HSD1-IN-1 (50-750 nM; 0-25 min) can inhibit T47D cells growth and 17β-HSD1 in a time-dependent manner[1]. Cell Cytotoxicity Assay[1] Cell Line:
In Vivo	Steroid sulfatase/17β-HSD1-IN-1 shows good metabolic stability in human hepatic S9 fraction (t1/2=47 min) and low intrinsic clearance Clint (15 μL/min/mg protein)[1].
Name	Steroid sulfatase/17β-HSD1-IN-1
Formula	C19H18N2O5S
Molar Mass	386.42
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Mohamed A, et al. Dual Targeting of Steroid Sulfatase and 17β-Hydroxysteroid Dehydrogenase Type 1 by a Novel Drug-Prodrug Approach: A Potential Therapeutic Option for the Treatment of Endometriosis. J Med Chem. 2022 Aug 22.

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